Regulator of G-protein signaling protein 18 integrates activating and inhibitory signaling in platelets
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PLATELETS AND THROMBOPOIESIS Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein for the G-q and G-i subunits of heterotrimeric Gproteins that turns off signaling by G-protein coupled receptors. RGS18 is highly expressed in platelets. In the present study, we show that the 14-3-3 protein binds to phosphorylated serines 49 and 218 of RGS18. Platelet activation by thrombin, thromboxaneA2, orADP stimula...
متن کاملRegulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.
Regulator of G-protein signaling 18 (RGS18) is a GTPase-activating protein for the G-α-q and G-α-i subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors. RGS18 is highly expressed in platelets. In the present study, we show that the 14-3-3γ protein binds to phosphorylated serines 49 and 218 of RGS18. Platelet activation by thrombin, thromboxane A2, or ADP...
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